circRNA basic information
circBase ID: -
Name: hsa_circ_THBS1
Synonym: hsa-THBS1_0001
Host Gene: THBS1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0012511
MONDO name: preterm premature rupture of the membranes
Disease details: preterm birth / PTB
Disease DO ID:
 0111144
Disease MeSH ID:
 C563032
Disease NCIt ID:
 C92862
Disease ICD11 ID:
 -
Disease OMIM ID:
 610504
Species: Human
Species details: Homo sapiens
Tissue specimen:

chorion
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: TGF-beta, NF-kappaB
Associated microRNA: -
Biological function: May mediate essential processes of ECM remodeling/collagen degradation and inflammatory responses at the maternal-fetal interface in PTB (inferred for DECs derived from ECM-related genes, including THBS1).
Molecular mechanism: Putative involvement of THBS1-related inflammatory signaling (TGF-beta and NF-kappaB pathways) discussed at host-gene level; not experimentally validated for the circRNA.
Biological pathway or process:

TGF-beta/SMAD (other); NF-kappaB (other); inflammation (other); fibrosis (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

This study identified hsa-THBS1_0001 as down-regulated in chorion in PTB versus term controls from RNA-seq reanalysis. The discussion links THBS1 to inflammatory pathways (TGF-beta and NF-kappaB) and maternal-fetal interface disruption, but this mechanism is not directly validated for the circRNA.
Confidence score:

0.1768
Other information
Title:

The landscape of circular RNA in preterm birth.

Journal: Frontiers in immunology
Published: 2022
PubMed ID: 36072601
Study type:

bioinformatics study
Data availability: SRP130149; GSE96077; ERP116770; SRP139931; GSE174415; GSE176127; GSE185557
Code availability: -