circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: hsa-HIPK3_0001 / circHIPK3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0012511
MONDO name: preterm premature rupture of the membranes
Disease details: preterm birth / PTB
Disease DO ID:
 0111144
Disease MeSH ID:
 C563032
Disease NCIt ID:
 C92862
Disease ICD11 ID:
 -
Disease OMIM ID:
 610504
Species: Human
Species details: Homo sapiens
Tissue specimen:

maternal plasma; cord blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: May aggravate PTB progression by causing excessive inflammation.
Molecular mechanism: Putative inflammatory regulation (mechanism in PTB not experimentally validated in this study).
Biological pathway or process:

inflammation (promotes)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

This study identified hsa-HIPK3_0001 (circHIPK3) as up-regulated in PTB (maternal plasma and cord blood) based on reanalysis of RNA-seq datasets. The authors propose it may contribute to PTB by promoting excessive immune-inflammatory responses.
Confidence score:

0.1768
Other information
Title:

The landscape of circular RNA in preterm birth.

Journal: Frontiers in immunology
Published: 2022
PubMed ID: 36072601
Study type:

bioinformatics study
Data availability: SRP130149; GSE96077; ERP116770; SRP139931; GSE174415; GSE176127; GSE185557
Code availability: -