| Expression pattern: |
UP |
| Associated gene: |
XRN2 |
| Associated microRNA: |
hsa-miR-1183 |
| Biological function: |
Promotes NSCLC tumor growth and induces macrophage M2 polarization. |
| Molecular mechanism: |
Exosomal hsa_circ_0003026 acts as a molecular sponge for hsa-miR-1183 to regulate XRN2 expression, thereby inducing macrophage M2 polarization and promoting NSCLC progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); macrophage polarization (promotes); immune regulation (promotes); proliferation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; Western Blot; ELISA; EdU Staining; CCK8; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Serum exosomal hsa_circ_0003026 is elevated in NSCLC patients and may have potential utility for early detection, disease monitoring, treatment response evaluation, and immunological assessment of the tumor microenvironment. |
| Description: |
This study shows that exosomal hsa_circ_0003026 is up-regulated in NSCLC patient serum and NSCLC cell line-derived exosomes. It promotes NSCLC growth by inducing macrophage M2 polarization through a hsa-miR-1183/XRN2 ceRNA-like regulatory axis, and it may serve as a serum exosomal biomarker or therapeutic target. |
| Confidence score: |
0.7751 |