| Expression pattern: |
UP |
| Associated gene: |
PAK1 |
| Associated microRNA: |
miR-485-5p |
| Biological function: |
promotes proliferation, migration/invasion and gemcitabine resistance; inhibits apoptosis in GEM-resistant pancreatic cancer cells |
| Molecular mechanism: |
ceRNA mechanism: circLMTK2 sponges miR-485-5p to regulate PAK1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; TUNEL; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Western Blot |
| Clinical significance: |
higher circLMTK2 expression led to poorer survival rate; potential diagnostic and prognostic biomarker in GEM-resistant PC |
| Description: |
circLMTK2 is up-regulated in pancreatic cancer and further increased in gemcitabine-resistant samples. It promotes GEM-resistant phenotypes by acting as a ceRNA that sponges miR-485-5p, thereby relieving repression of PAK1 and enhancing proliferation/migration/invasion while inhibiting apoptosis; silencing circLMTK2 reduces tumor growth in a xenograft model. |
| Confidence score: |
0.7859 |