| Expression pattern: |
UP |
| Associated gene: |
IGF2BP1, IGF2BP2, IGF2BP3, Slug, P-Smad2, P-Smad3 |
| Associated microRNA: |
miR-203 |
| Biological function: |
promotes cervical cancer metastasis and EMT; stabilizes Slug mRNA |
| Molecular mechanism: |
CDR1as binds IGF2BP1 and facilitates IGF2BP1 binding to m6A-modified Slug mRNA, increasing Slug mRNA stability; activates TGF-beta signaling (p-SMAD2/p-SMAD3) to promote EMT/metastasis; miRNA sponge mechanism not supported for Slug in this study |
| Biological pathway or process: |
TGF-beta/SMAD (promotes); EMT (promotes); metastasis (promotes); migration (promotes); invasion (promotes); m6A modification (other); mRNA stability (promotes) |
| Detected method: |
Q
H
S
M
|
| Validation methods: |
RNA-seq; Microarray; RT-qPCR; RNase R Treatment; divergent primers PCR; Sanger Sequencing; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); Clinical Sample Validation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Higher CDR1as expression was associated with lymph node metastasis and shorter overall survival/worse prognosis in cervical cancer patients. |
| Description: |
In cervical cancer, CDR1as is up-regulated after TGF-beta activation and promotes migration/invasion, EMT, and metastasis. Mechanistically, CDR1as binds IGF2BP1 and enhances IGF2BP1-mediated stabilization of Slug mRNA (m6A-related), and it activates TGF-beta/SMAD signaling (p-SMAD2/p-SMAD3), correlating clinically with lymph node metastasis and poorer survival. |
| Confidence score: |
0.8776 |