circRNA basic information
circBase ID: hsa_circ_0089761
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chrM:7586-15888:-
Genomic location(hg38): chrM:7585-15887:-
Subcellular localization: mitochondria; cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007027
MONDO name: metabolic dysfunction-associated steatohepatitis
Disease details: Nonalcoholic steatohepatitis / NASH
Disease DO ID:
 0080547
Disease MeSH ID:
 -
Disease NCIt ID:
 C84445
Disease ICD11 ID:
 1884917970
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

liver tissue
Cell lines:

LX-2
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: SMAD2, SMAD3, c-MYC
Associated microRNA: hsa-mir-136-5p, hsa-mir-154-3p, hsa-mir-155-3p, hsa-mir-195-3p, hsa-mir-345-5p, hsa-mir-365a-3p, hsa-mir-365b-3p, hsa-mir-374a-5p, hsa-mir-384, hsa-mir-3943, hsa-mir-4705, hsa-mir-4732-3p, hsa-mir-5003-5p, hsa-mir-5193, hsa-mir-548aa, hsa-mir-548as-3p, hsa-mir-548t-3p, hsa-mir-5583-5p, hsa-mir-6511a-3p, hsa-mir-6511b-3p, hsa-mir-664a-3p, hsa-mir-6729-3p, hsa-mir-6731-3p, hsa-mir-6758-3p, hsa-mir-7844-5p, hsa-mir-487a-3p
Biological function: regulate fibrosis-related signals in hepatic stellate cells (HSCs) in NASH
Molecular mechanism: ceRNA mechanism (miRNA sponge) via mecciRNA-miRNA-mRNA network
Biological pathway or process:

TGF-beta/SMAD (other); Hippo/YAP (other); fibrosis (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Transfection; In Vivo Animal Model; Western Blot
Clinical significance:

-
Description:

hsa_circ_0089761 is down-regulated in NASH HSCs and in LPS-activated LX-2 cells. It is proposed to act as a ceRNA/miRNA sponge in a mecciRNA-miRNA-mRNA network, potentially regulating fibrosis-related signaling (including enrichment of TGF-beta and Hippo pathways) with core downstream targets such as SMAD2/3 and c-MYC.
Confidence score:

0.508
Other information
Title:

The potential of mecciRNA in hepatic stellate cell to regulate progression of nonalcoholic hepatitis.

Journal: Journal of translational medicine
Published: 2022
PubMed ID: 36058953
Study type:

combined biological and clinical study
Data availability: GSE134146; GSE46300; 10.1186/s12967-022-03595-1
Code availability: -