| Expression pattern: |
DN |
| Associated gene: |
NFKBIA |
| Associated microRNA: |
miR-942-5p, miR-6077 |
| Biological function: |
circ-CEP85L suppresses GC cell proliferation, colony formation, motility, invasion, and in vivo tumor growth; knockdown of circ-CEP85L promotes proliferation and invasion. |
| Molecular mechanism: |
circ-CEP85L acts as a ceRNA by sponging miR-942-5p to promote NFKBIA expression, thereby inhibiting GC proliferation and invasion. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other); metastasis (inhibits); EMT (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Decreased circ-CEP85L expression correlates with worse prognosis and is associated with T stage, lymph node metastasis, and TNM stage in GC patients. |
| Description: |
circ-CEP85L is downregulated in gastric cancer tissues and low expression is associated with worse prognosis. Functionally, circ-CEP85L suppresses GC cell proliferation, migration, invasion, and in vivo tumor growth. Mechanistically, it acts as a ceRNA for miR-942-5p to promote NFKBIA expression, suggesting potential therapeutic relevance in GC. |
| Confidence score: |
0.8155 |