circRNA basic information
circBase ID: -
Name: hsa_circ_SP1
Synonym: circRNA4746
Host Gene: SP1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

HPV negative normal cervical epithelium; HPV16 positive normal cervical epithelium; HPV16 positive high-grade squamous intraepithelial lesion; HPV16 positive cervical squamous epithelial cell carcinoma tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NOP56, ELAVL1, SF3B4, CELF2, RC3H1, CNBP, UPF1, FMR1, CPSF6, DGCR8, SRSF1, NOP58, SRSF3, U2AF1, U2AF2, TIAL1, DDX54, RBM10, PCBP2, SF3A3, PTBP1, HNRNPC, TRA2A, ZNF184, HNRNPA1, DDX3X, ZC3H7B, LARP7, SMNDC1, MSI2, ACIN1, LIN28B, RANGAP1, FXR1, FXR2, SND1, IGF2BP1, BUD13, IGF2BP2, IGF2BP3, HNRNPUL1, GTF2F1, RBFOX2, PRPF8, SLTM, EIF4G2, DDX42, CSTF2T, RNF219, XRN2, HNRNPK, AGO2, AGO1, EIF4A3, FBL
Associated microRNA: hsa-miR-215-3p, hsa-miR-197-3p, hsa-miR-92a-1-5p, hsa-miR-125a-3p
Biological function: Potential ceRNA involved in cervical cancer progression.
Molecular mechanism: Predicted ceRNA mechanism via hsa-miR-215-3p, hsa-miR-197-3p, hsa-miR-92a-1-5p, and hsa-miR-125a-3p; predicted RBP interactions.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
S
Validation methods:

Bioinformatics Analysis; RNA-seq
Clinical significance:

Potential biomarker and therapeutic target for cervical cancer progression.
Description:

circRNA4746/hsa-SP1_00031 was identified as an up-regulated DE circRNA in CSCC relative to HPV-positive and HPV-negative normal cervical epithelium. It was predicted to function in the ceRNA network through several miRNAs and to interact with many RBPs.
Confidence score:

0.1768
Other information
Title:

Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.

Journal: Journal of applied genetics
Published: 2025
PubMed ID: 40531429
Study type:

bioinformatics study
Data availability: GSE147009; TCGA; CircAtlas; Transcirc; MiRWalk 3.0; CMAP2; CTDBASE
Code availability: -