| Expression pattern: |
DN |
| Associated gene: |
ACTB, AGO2 |
| Associated microRNA: |
miR-206 |
| Biological function: |
Acts as a ceRNA (miRNA sponge) for miR-206 to increase ACTB expression, contributing to HCM occurrence/progression. |
| Molecular mechanism: |
ceRNA regulation: circFN1 competitively binds miR-206 (AGO2-associated) thereby relieving repression of ACTB. |
| Biological pathway or process: |
ceRNA regulation (promotes); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); FISH / smFISH; Bioinformatics Analysis; Transfection |
| Clinical significance: |
Potential blood circulation marker for HCM. |
| Description: |
In HCM peripheral blood, circFN1 is down-regulated. circFN1 acts as a ceRNA by binding miR-206 (AGO2-associated), thereby relieving miR-206-mediated repression of ACTB and contributing to HCM occurrence/progression. |
| Confidence score: |
0.6521 |