circRNA basic information
circBase ID: hsa_circ_0056281
Name: hsa_circ_EPB41L5
Synonym: hsa_circRNA_0056281
Host Gene: EPB41L5
Genomic location(hg19): chr2:120885263-120922486:+
Genomic location(hg38): chr2:120127687-120164910:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004981
MONDO name: atrial fibrillation
Disease details: atrial fibrillation / AF
Disease DO ID:
 0060224
Disease MeSH ID:
 D001281
Disease NCIt ID:
 C50466
Disease ICD11 ID:
 171698302
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

heart tissues (left atrial appendages)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CXCR4, CXCR2, CXCL11
Associated microRNA: hsa-miR-613
Biological function: May be involved in AF pathogenesis, potentially related to atrial fibrosis and structural remodeling.
Molecular mechanism: ceRNA network prediction: hsa_circ_0056281 may sponge hsa-miR-613 to regulate CXCR4/CXCR2/CXCL11.
Biological pathway or process:

ceRNA regulation (other); inflammation (other); immune regulation (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0056281 is upregulated in AF atrial appendage tissue and is predicted to act in a ceRNA axis by interacting with hsa-miR-613 and thereby regulating CXCR4/CXCR2/CXCL11, potentially contributing to AF-related inflammation/atrial remodeling processes.
Confidence score:

0.1768
Other information
Title:

Bioinformatics analysis of the circRNA-miRNA-mRNA network for atrial fibrillation.

Journal: Medicine
Published: 2022
PubMed ID: 36042613
Study type:

bioinformatics study
Data availability: GSE129409; GSE68475; GSE79768
Code availability: -