| Expression pattern: |
UP |
| Associated gene: |
HMGA2, beta-catenin, c-Myc |
| Associated microRNA: |
hsa-miR-532-3p |
| Biological function: |
Promotes hREC viability under hyperglycemia, including DNA synthesis, proliferation, migration, wound healing, and tube formation; contributes to retinal neovascularization and DR progression. |
| Molecular mechanism: |
hsa_circ_0002629 directly binds hsa-miR-532-3p and regulates DR development via the hsa_circ_0002629/hsa-miR-532-3p/HMGA2 signaling pathway, influencing HMGA2, beta-catenin phosphorylation, and c-Myc protein expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); angiogenesis (promotes); fibrosis (promotes); Wnt/beta-catenin (promotes); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNase R Treatment; RT-qPCR; RNA-seq; FISH / smFISH; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Tube Formation Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); IF (Immunofluorescence); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
May represent a promising target for clinical diagnosis and treatment of diabetic retinopathy. |
| Description: |
hsa_circ_0002629 is up-regulated in aqueous humor from DR patients and in high-glucose-treated hRECs. It promotes hREC proliferation, DNA synthesis, migration, wound healing, and tube formation by interacting with hsa-miR-532-3p and regulating the HMGA2-related signaling pathway, including beta-catenin phosphorylation and c-Myc expression. The hsa_circ_0002629/hsa-miR-532-3p/HMGA2 axis is proposed as a potential diagnostic and therapeutic target for diabetic retinopathy. |
| Confidence score: |
0.7956 |