| Expression pattern: |
UP |
| Associated gene: |
PRDX2, ELANE, TNF-alpha |
| Associated microRNA: |
- |
| Biological function: |
Aggravates hallmarks of COPD and promotes inflammation after PM2.5 exposure. |
| Molecular mechanism: |
Exosomal circRNA physically binds PRDX2, forms a complex associated with ELANE, and activates PRDX2/ELANE/TNF-alpha signaling to aggravate COPD lesions/inflammation. |
| Biological pathway or process: |
inflammation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Co-IP; Western Blot; ELISA; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
Relatively high exosomal hsa_circ_0005045 expression characterizes PM2.5 exposure-sensitive COPD patients at risk of acute exacerbation and is used as a feature in machine learning prediction models. |
| Description: |
This study identifies exosomal hsa_circ_0005045 as PM2.5-inducible and elevated in COPD patient plasma after exposure. It binds PRDX2 in exosomes and is linked to PRDX2/ELANE/TNF-alpha inflammatory signaling that aggravates COPD-like lesions, and its higher level helps characterize PM2.5-sensitive COPD patients at risk of aeCOPD. |
| Confidence score: |
0.8323 |