circRNA basic information
circBase ID: -
Name: hsa_circ_MAN1A2
Synonym: circMAN1A2
Host Gene: MAN1A2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015459
MONDO name: nasopharyngeal carcinoma
Disease details: nasopharyngeal carcinoma
Disease DO ID:
 9261
Disease MeSH ID:
 D00007727; D000077274
Disease NCIt ID:
 C3871
Disease ICD11 ID:
 1883313543
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

5-8F
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SLC4A8, IKZF4, SMAGP, SP1, ERBB3, CBX5
Associated microRNA: hsa-miR-135a-3p
Biological function: unknown
Molecular mechanism: Predicted ceRNA mechanism via binding miRNAs (most likely hsa-miR-135a-3p) and affecting putative target genes (SLC4A8, IKZF4, SMAGP, SP1, ERBB3, CBX5); not experimentally validated.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

circMAN1A2 is upregulated in patient sera and shows diagnostic value (AUC 0.911 in NPC; 0.779 oral cancer; 0.734 thyroid cancer; 0.694 ovarian cancer; 0.645 lung cancer).
Description:

circMAN1A2 is significantly up-regulated in patient serum across several malignancies (NPC, oral, thyroid, ovarian, and lung cancer) and shows diagnostic potential by ROC analysis. A ceRNA-style mechanism (binding miRNAs, especially hsa-miR-135a-3p, with predicted downstream targets) is proposed but not experimentally validated in this study.
Confidence score:

0.459
Other information
Title:

circMAN1A2 could serve as a novel serum biomarker for malignant tumors.

Journal: Cancer science
Published: 2019
PubMed ID: 31046163
Study type:

combined biological and clinical study
Data availability: -
Code availability: -