| Expression pattern: |
UP |
| Associated gene: |
YAP1 |
| Associated microRNA: |
miR-6820-3p |
| Biological function: |
promotes proliferation, migration, invasion, metastasis, and tumorigenesis of PDAC |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-6820-3p to relieve repression of YAP1, increasing YAP1 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; FISH / smFISH; ISH (In Situ Hybridization); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Higher hsa_circ_0007367 expression was correlated with advanced histological grade and lymph node metastasis in PDAC patients, and was positively correlated with poorer prognosis. |
| Description: |
hsa_circ_0007367 (derived from UBAP2) is up-regulated in PDAC tissues and cell lines and predominantly localizes to the cytoplasm. It promotes PDAC proliferation, migration/invasion, and tumor growth by acting as a ceRNA that sponges miR-6820-3p, thereby upregulating YAP1. Clinically, high hsa_circ_0007367 is associated with aggressive clinicopathological features and poorer prognosis in PDAC. |
| Confidence score: |
0.8456 |