| Expression pattern: |
UP |
| Associated gene: |
ZEB2, DDX42 |
| Associated microRNA: |
miR-625 |
| Biological function: |
Promotes endometrial cancer cell proliferation, invasion, EMT, tumorigenicity, and paclitaxel resistance; inhibits paclitaxel-induced apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-625 to increase the expression of the miR-625 target gene ZEB2, thereby promoting EMT and paclitaxel resistance. |
| Biological pathway or process: |
EMT (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High circ_0007534 expression was associated with poor differentiation, advanced tumor stage, invasion, metastasis, and poor prognosis in endometrial cancer patients. |
| Description: |
circ_0007534 is up-regulated in endometrial cancer and mainly localized in the cytoplasm. It promotes proliferation, invasion, EMT, and paclitaxel resistance by sponging miR-625 and thereby increasing ZEB2 expression, and its high expression is associated with poor prognosis. |
| Confidence score: |
0.7846 |