| Expression pattern: |
DS |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-7-5p, hsa-miR-6766-3p, hsa-miR-490-5p |
| Biological function: |
Potential oncogenic role; associated with metastasis and poor overall survival; proposed miRNA sponging effect on hsa-miR-7-5p. |
| Molecular mechanism: |
Proposed ceRNA/miRNA sponge mechanism: ciRS-7 negatively correlates with hsa-miR-7-5p and may act as its sponge in EOC plasma. |
| Biological pathway or process: |
metastasis (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
Circulating ciRS-7 in plasma shows diagnostic value (ROC/AUC) and higher expression is associated with lymph node invasion, distant metastasis, and worse overall survival; it is an independent predictor of OS in advanced-stage (FIGO IIB-IV) EOC. |
| Description: |
This study reports that circulating ciRS-7 is aberrantly expressed in EOC plasma (higher preoperatively) and has diagnostic value by ROC analysis. High ciRS-7 levels are associated with lymph node/distant metastasis and worse overall survival, and ciRS-7 is an independent prognostic factor in advanced-stage EOC. Mechanistically, it is proposed to act as a sponge for hsa-miR-7-5p based on predicted binding and an inverse plasma correlation. |
| Confidence score: |
0.5339 |