circRNA basic information
circBase ID: hsa_circ_0005050
Name: hsa_circ_XPO1
Synonym: circXPO1
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OSCC tissues; corresponding adjacent normal tissues; tumor tissues
Cell lines:

HOK; HSC3; HSC-3; SCC25; CAL27; SCC9
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CCND1 / cyclin D1
Associated microRNA: miR-524-5p
Biological function: circXPO1 promotes OSCC cell proliferation, migration, invasion, glycolysis and tumor growth, and inhibits apoptosis; knockdown of circXPO1 suppresses these malignant phenotypes and promotes apoptosis.
Molecular mechanism: circXPO1 acts as a miR-524-5p sponge and regulates CCND1 expression through miR-524-5p in OSCC cells.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); apoptosis (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; Colony Formation Assay; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis
Clinical significance:

circXPO1 may be a potential target for OSCC treatment.
Description:

circXPO1 is an up-regulated, cytoplasmic circRNA in OSCC tissues and cell lines. Functionally, circXPO1 promotes OSCC proliferation, migration, invasion, glycolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circXPO1 sponges miR-524-5p to regulate CCND1 expression, suggesting therapeutic relevance for OSCC.
Confidence score:

0.8174
Other information
Title:

Knockdown of circXPO1 inhibits the development of oral squamous cell carcinoma cells.

Journal: Oral diseases
Published: 2024
PubMed ID: 38622909
Study type:

combined biological and clinical study
Data availability: -
Code availability: -