| Expression pattern: |
UP |
| Associated gene: |
LUZP1, YY1, AGO2 |
| Associated microRNA: |
miR-486-3p, miR-1225-5p |
| Biological function: |
promotes osteosarcoma progression, lung metastasis and angiogenesis; promotes proliferation, migration and invasion; promotes neovascularization |
| Molecular mechanism: |
YY1 activates circFIRRE transcription; circFIRRE acts as a miRNA sponge for miR-486-3p and miR-1225-5p to upregulate LUZP1 (mRNA and protein), promoting tumorigenesis and angiogenesis |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); angiogenesis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RNase R Treatment; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high circFIRRE expression is associated with higher metastatic risk and worse prognosis; circFIRRE is an independent risk factor for OS and may be a prognostic biomarker/therapeutic target |
| Description: |
circFIRRE (hsa_circ_0001944) is upregulated in osteosarcoma tissues and cell lines and promotes tumor growth, migration/invasion, angiogenesis and lung metastasis. Mechanistically, YY1 activates circFIRRE, which sponges miR-486-3p and miR-1225-5p to upregulate LUZP1, contributing to tumorigenic-angiogenic coupling and poor prognosis. |
| Confidence score: |
0.8933 |