| Expression pattern: |
UP |
| Associated gene: |
PDLIM4, Ago2 |
| Associated microRNA: |
miR-629-3p |
| Biological function: |
promotes proliferation and invasion; inhibits oxidative stress (reduces ROS; increases SOD, CAT, GSH-Px) |
| Molecular mechanism: |
acts as a miRNA sponge for miR-629-3p to upregulate PDLIM4 expression |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); oxidative stress (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Colony Formation Assay; Transwell Assay; ELISA; Western Blot |
| Clinical significance: |
may be a useful marker for predicting GC prognosis and an anti-GC treatment target |
| Description: |
hsa_circ_0002360 (circ0002360) is up-regulated in gastric cancer cell lines and mainly enriched in the cytoplasm. It promotes proliferation and invasion and suppresses oxidative stress by sponging miR-629-3p, thereby increasing PDLIM4 expression. |
| Confidence score: |
0.7437 |