circRNA basic information
circBase ID: hsa_circ_0045602
Name: hsa_circ_HN1
Synonym: circ-HN1
Host Gene: HN1
Genomic location(hg19): chr17:73142760-73144766:-
Genomic location(hg38): chr17:75146665-75148671:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; para-carcinoma tissues / tumor-adjacent tissues
Cell lines:

GES-1; HGC-27; AGS; SGC-7901; MKN-28; GC-7901
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: GSK3A
Associated microRNA: miR-485-5p
Biological function: Promotes GC cell proliferation, migration, and invasion.
Molecular mechanism: Acts as a ceRNA by sponging miR-485-5p, thereby regulating GSK3A.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RNA Pull-Down; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Clinical Sample Validation
Clinical significance:

Potential therapeutic target for GC.
Description:

circ-HN1 is up-regulated in gastric cancer tissues and cell lines and functions as a tumor promoter. Mechanistically, circ-HN1 sponges miR-485-5p to relieve repression of GSK3A, thereby promoting proliferation, migration, and invasion of GC cells; circ-HN1 knockdown suppresses these phenotypes.
Confidence score:

0.7551
Other information
Title:

Downregulation of circular RNA circ-HN1 suppressed the progression of gastric cancer through the miR-485-5p/GSK3A pathway.

Journal: Bioengineered
Published: 2022
PubMed ID: 34607506
Study type:

combined biological and clinical study
Data availability: -
Code availability: -