circRNA basic information
circBase ID: -
Name: hsa_circ_BIRC6
Synonym: Circular RNA BIRC6 / circBIRC6
Host Gene: BIRC6
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005076
MONDO name: periodontitis
Disease details: periodontitis
Disease DO ID:
 824, 9893
Disease MeSH ID:
 D010518
Disease NCIt ID:
 C34918
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

periodontitis tissues; healthy periodontal tissues; periodontal ligament tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PTEN, AGO2, PI3K, AKT, mTOR
Associated microRNA: miR-543
Biological function: Acts as a negative regulator of PDLSC osteogenic differentiation and mineralization under inflammatory conditions.
Molecular mechanism: circBIRC6 functions as a ceRNA by sponging miR-543, thereby regulating PTEN and downstream PI3K/AKT/mTOR signaling to modulate osteogenic differentiation/mineralization.
Biological pathway or process:

PI3K/AKT/mTOR (inhibits); osteogenic differentiation (inhibits); mineralization (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; IF (Immunofluorescence); MTT; EdU Staining; Cell Cycle Assay
Clinical significance:

Targeting circBIRC6 might represent a potential therapeutic strategy for improving bone loss in periodontitis.
Description:

circBIRC6 is up-regulated in inflamed PDLSCs and periodontitis tissues and functions as a negative regulator of osteogenic differentiation/mineralization. It sponges miR-543 to modulate PTEN and thereby affects PI3K/AKT/mTOR signaling in the inflammatory microenvironment.
Confidence score:

0.7087
Other information
Title:

Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.

Journal: Stem cell research & therapy
Published: 2022
PubMed ID: 35964136
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -