circRNA basic information
circBase ID: hsa_circ_0000977
Name: hsa_circ_NOL10
Synonym: circ-NOL10
Host Gene: NOL10
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: nucleus
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KLF9
Associated microRNA: miR-135a-5p, miR-135b-5p
Biological function: inhibits proliferation; inhibits progression; inhibits migration
Molecular mechanism: May function as a ceRNA by sponging miR-135a-5p and miR-135b-5p to regulate KLF9 in CRC.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

circ-NOL10 could be used as a diagnostic marker for CRC (AUC 80.3%, sensitivity 70%, specificity 95%).
Description:

In CRC patient blood, circ-NOL10 is significantly up-regulated versus healthy controls and shows diagnostic value. The paper discusses that circ-NOL10 may inhibit CRC cell proliferation and migration via a ceRNA mechanism involving miR-135a/b-5p and KLF9.
Confidence score:

0.4187
Other information
Title:

Expression status of circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1 in patients with colorectal cancer.

Journal: Scientific reports
Published: 2023
PubMed ID: 37587156
Study type:

clinical study
Data availability: All data generated or analyzed during this study are included in this published article.
Code availability: -