| Expression pattern: |
UP |
| Associated gene: |
EZH2 |
| Associated microRNA: |
miR-600 |
| Biological function: |
Promotes CRC cell viability, proliferation, invasion, migration, tumor growth and CRC progression; hsa_circ_0071589 knockdown inhibits these malignant phenotypes. |
| Molecular mechanism: |
hsa_circ_0071589 acts as a sponge of miR-600 to promote EZH2 expression, forming the hsa_circ_0071589/miR-600/EZH2 regulatory axis in CRC. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); migration (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Microarray; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0071589 expression is associated with pathological metastasis, clinical stage, lymph node metastasis, and shorter overall survival; it may serve as a novel therapy target in CRC. |
| Description: |
hsa_circ_0071589 is up-regulated in colorectal cancer tissues and its high expression is associated with advanced clinical features and shorter overall survival. Functionally, it promotes CRC cell viability, proliferation, invasion and migration. Mechanistically, it acts as a miR-600 sponge to increase EZH2 expression, forming a hsa_circ_0071589/miR-600/EZH2 oncogenic regulatory axis. |
| Confidence score: |
0.817 |