| Expression pattern: |
UP |
| Associated gene: |
HDGF |
| Associated microRNA: |
miR•185•5p |
| Biological function: |
CircRAD18 promotes daunorubicin resistance and proliferation of AML drug-resistant KG1a cells under DNR treatment and inhibits apoptosis; CircRAD18 knockdown weakens DNR resistance, suppresses proliferation, and promotes apoptosis. |
| Molecular mechanism: |
CircRAD18 acts through a ceRNA-like miR•185•5p/HDGF axis: CircRAD18 targets and down-regulates miR•185•5p, thereby promoting HDGF expression and DNR resistance. |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; IF (Immunofluorescence); Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
This study shows that CircRAD18 is up-regulated in the human AML daunorubicin-resistant KG1a cell line. CircRAD18 promotes DNR resistance by targeting miR•185•5p and increasing HDGF expression; knockdown of CircRAD18 restores DNR sensitivity, inhibits proliferation, and promotes apoptosis. |
| Confidence score: |
0.5607 |