| Expression pattern: |
UP |
| Associated gene: |
HGF, c-Met, Ago2 |
| Associated microRNA: |
miR-526b-5p |
| Biological function: |
CircEIF3I promotes HCC cell proliferation, colony formation, EMT, migration, invasion, angiogenesis and in vivo tumor growth, while inhibiting apoptosis. |
| Molecular mechanism: |
CircEIF3I acts as a ceRNA by sponging miR-526b-5p, thereby regulating HGF expression and the HGF/c-Met signaling pathway in HCC. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); angiogenesis (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
High circEIF3I expression was associated with tumor size and TNM stage in HCC patients; the study suggests circEIF3I/miR-526b-5p axis as a potential therapeutic target in HCC. |
| Description: |
CircEIF3I is up-regulated in HCC tissues and cells and functions as an oncogenic circRNA. It promotes malignant growth, EMT, migration, invasion, angiogenesis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circEIF3I sponges miR-526b-5p to regulate HGF and the HGF/c-Met signaling pathway, suggesting therapeutic potential for targeting the circEIF3I/miR-526b-5p/HGF axis in HCC. |
| Confidence score: |
0.8512 |