circRNA basic information
circBase ID: hsa_circ_0003823
Name: hsa_circ_CEP70
Synonym: circ0003823
Host Gene: CEP70
Genomic location(hg19): chr3:138289159-138291826:-
Genomic location(hg38): chr3:138570317-138572984:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; paired non-tumorous tissues
Cell lines:

SK-Hep1 / SK-hep1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-182-5p, miR-561-3p, miR-7155-5p, miR-6762-3p, miR-6085
Biological function: Suppresses HCC cell proliferation and migration (knockdown promotes both).
Molecular mechanism: Predicted ceRNA network with candidate miRNAs.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; divergent primers PCR; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0003823 is down-regulated in non-cirrhotic HCC and acts as a tumor-suppressive circRNA in vitro, since its knockdown promotes SK-Hep1 cell growth and migration. Candidate miRNAs were predicted within a circRNA-miRNA-mRNA network.
Confidence score:

0.7244
Other information
Title:

High-throughput circular RNA sequencing reveals the profiles of circular RNA in non-cirrhotic hepatocellular carcinoma.

Journal: BMC cancer
Published: 2022
PubMed ID: 35931993
Study type:

combined biological and clinical study
Data availability: GSE193862
Code availability: Additional file 1: Supplementary materials