circRNA basic information
circBase ID: hsa_circ_0050334
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr19:30462099-30477324:+
Genomic location(hg38): chr19:29971192-29986417:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RGS2
Associated microRNA: hsa_miR_182_5p
Biological function: Promotes colorectal cancer progression; potentially participates in immune responses in the tumor microenvironment via the Exo-ceRNA subnetwork.
Molecular mechanism: Exo-ceRNA mechanism via hsa_miR_182_5p to increase RGS2 expression.
Biological pathway or process:

ceRNA regulation (promotes); immune regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis; Survival Analysis
Clinical significance:

Part of a survival-related Exo-ceRNA subnetwork built around prognostic target gene RGS2; suggests potential therapeutic target in CRC.
Description:

hsa_circ_0050334 is an exosomal circRNA implicated via bioinformatics in a CRC survival-related ceRNA subnetwork (hsa_circ_0050334-hsa_miR_182_5p-RGS2), proposed to promote CRC progression and relate to immune infiltration (not experimentally validated for circRNA expression in this paper’s clinical qPCR section).
Confidence score:

0.348
Other information
Title:

Integrated analysis of the functions and clinical implications of exosome circRNAs in colorectal cancer.

Journal: Frontiers in immunology
Published: 2022
PubMed ID: 35924235
Study type:

bioinformatics study
Data availability: exoRBase 2.0; GSE156732; COAD; READ
Code availability: -