| Expression pattern: |
DN |
| Associated gene: |
HNRNPC, U2AF2, AGO2, ELAVL1, HNRNPA1, TARDBP |
| Associated microRNA: |
- |
| Biological function: |
inhibits proliferation; inhibits migration/invasion; inhibits colony formation; inhibits tumour growth |
| Molecular mechanism: |
Predicted to act via interactions with microRNAs and RNA-binding proteins (protein traps/miRNA sponges) based on bioinformatic analyses; no specific miRNA experimentally validated. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Colony Formation Assay; In Vivo Animal Model |
| Clinical significance: |
Lower serum exosomal circ_0061407 levels were associated with advanced pathological staging and distant metastasis; shows diagnostic value for NSCLC (ROC AUC reported). |
| Description: |
Serum exosomal circ_0061407 is down-regulated in NSCLC and acts as a tumor-suppressive circRNA: its overexpression (including exosome-mediated delivery) inhibits NSCLC-related proliferation, migration/invasion, colony formation, and xenograft tumor growth. It shows diagnostic potential for NSCLC and correlates with distant metastasis/advanced stage; mechanisms were mainly predicted via miRNA/mRNA networks and RBP interactions. |
| Confidence score: |
0.7588 |