circRNA basic information
circBase ID: hsa_circ_0007813
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr10:12123470-12162266:+
Genomic location(hg38): chr10:12081471-12120267:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissue; normal liver tissue; fresh tumor tissues; paired adjacent non-tumor tissues; adjacent paired tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: 80 DEmRNAs
Associated microRNA: hsa_miR_139-5p
Biological function: May act as a ceRNA in HCC by competitively binding hsa_miR_139-5p and regulating high expression of 80 DEmRNAs; may be useful for predicting and diagnosing HCC.
Molecular mechanism: ceRNA mechanism involving circRNA-miRNA-mRNA regulatory network; hsa_circ_0007813 competitively combines with hsa_miR_139-5p to regulate DEmRNA expression.
Biological pathway or process:

ceRNA regulation (other); cell cycle (promotes); proliferation (other)
Detected method:
S
Validation methods:

RNA-seq; ROC Analysis; Bioinformatics Analysis
Clinical significance:

ROC analysis suggested diagnostic potential; AUC was 0.667 and 0.875 in GSE125469 and GSE128274, respectively.
Description:

hsa_circ_0007813 was identified as an up-regulated HCC-related circRNA by bioinformatic reanalysis of GEO RNA-seq datasets. The study proposes that it may function as a ceRNA by binding hsa_miR_139-5p and regulating 80 DEmRNAs, with possible relevance to HCC occurrence, progression, and diagnosis.
Confidence score:

0.348
Other information
Title:

Construction of ceRNA network and identification of two differentially expressed circRNAs in hepatocellular carcinoma by bioinformatic analysis.

Journal: International journal of clinical and experimental pathology
Published: 2020
PubMed ID: 33284888
Study type:

bioinformatics study
Data availability: GSE125469; GSE128274; Gene Expression Omnibus (GEO) database
Code availability: -