| Expression pattern: |
UP |
| Associated gene: |
FSTL1 |
| Associated microRNA: |
miR-873-5p |
| Biological function: |
promotes PTC cell proliferation, migration, and invasion; promotes xenograft tumor growth |
| Molecular mechanism: |
ceRNA mechanism: circ_0058129 sponges miR-873-5p to regulate FSTL1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Cell Cycle Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_0058129 is up-regulated in papillary thyroid cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes PTC proliferation, cell-cycle progression, migration/invasion and xenograft tumor growth by sponging miR-873-5p, thereby relieving repression of FSTL1 (circ_0058129/miR-873-5p/FSTL1 ceRNA axis). |
| Confidence score: |
0.82 |