circRNA basic information
circBase ID: hsa_circ_0001411
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr4:54249939-54256040:+
Genomic location(hg38): chr4:53383772-53389873:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for CRC (in serum exosomes).
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Included in a 6-Exo-circRNA diagnostic model distinguishing CRC from controls (AUC 0.744 training; 0.741 validation).
Description:

hsa_circ_0001411 is up-regulated in serum exosomes from CRC patients and contributes to a 6-exosomal circRNA diagnostic model validated in external GEO cohorts.
Confidence score:

0.5047
Other information
Title:

Integrated analysis of the functions and clinical implications of exosome circRNAs in colorectal cancer.

Journal: Frontiers in immunology
Published: 2022
PubMed ID: 35924235
Study type:

combined biological and clinical study
Data availability: exoRBase 2.0; GSE156732; GSE100063; GSE100206; COAD; READ; IMvigor210; GSE67501; GSE78220
Code availability: -