| Expression pattern: |
UP |
| Associated gene: |
E-cadherin, N-cadherin, Vimentin |
| Associated microRNA: |
- |
| Biological function: |
circ_0067934 functions as an oncogenic circular RNA and tumor promoter in NSCLC; its down-regulation suppresses NSCLC cell proliferation, migration and invasion and inhibits EMT. |
| Molecular mechanism: |
circ_0067934 promotes NSCLC progression by modulating epithelial-to-mesenchymal transition, increasing mesenchymal markers N-cadherin and Vimentin and reducing epithelial marker E-cadherin when active. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Transwell Assay; Western Blot; Cohort Study; Survival Analysis |
| Clinical significance: |
High circ_0067934 expression is associated with high TNM stage, positive lymph node status, distant metastasis, shorter overall survival, and is an independent poor prognostic factor in NSCLC. |
| Description: |
circ_0067934 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. Its knockdown suppresses NSCLC cell proliferation, migration and invasion, likely through inhibition of EMT marker changes. Clinically, high circ_0067934 expression is associated with advanced disease features and poorer overall survival, suggesting prognostic and therapeutic relevance. |
| Confidence score: |
0.6527 |