| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
microRNA-21 (miR-21), microRNA-31 (miR-31) |
| Biological function: |
circ_0026344 suppresses CRC progression by inhibiting CRC cell proliferation, invasion and in vivo tumor growth, while promoting apoptosis. |
| Molecular mechanism: |
circ_0026344 acts as a miRNA sponge for miR-21 and miR-31; rescue assays showed that circ_0026344 exerts tumor-suppressive functions through sponging miR-21 and miR-31. |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); apoptosis (promotes); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0026344 low expression was inversely correlated with CRC advance and lymphoid node metastasis and predicted poor prognosis; circ_0026344 may be a reliable prognostic biomarker in CRC patients. |
| Description: |
circ_0026344 is down-regulated in colorectal cancer tissues and cell lines, and lower expression is associated with advanced stage, lymphoid node metastasis and poor prognosis. Functionally, circ_0026344 acts as a tumor suppressor by inhibiting CRC proliferation, invasion and xenograft growth while promoting apoptosis. Mechanistically, it sponges miR-21 and miR-31, forming a circ_0026344/miR-21/miR-31 regulatory axis in CRC progression. |
| Confidence score: |
0.7588 |