| Expression pattern: |
UP |
| Associated gene: |
STAT3, Bcl-2 |
| Associated microRNA: |
miR-370-3p |
| Biological function: |
promotes proliferation, migration, invasion, metastasis and glycolysis; inhibits autophagy |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-370-3p to activate STAT3 signaling, affecting EMT, autophagy and glycolysis; exosomal circUBE2Q2 mediates intercellular communication to promote metastasis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); glycolysis (promotes); autophagy (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
may be a meaningful diagnostic or prognostic marker; circUBE2Q2 levels are higher in plasma exosomes of GC patients; correlated with tumor size and lymphatic invasion |
| Description: |
circUBE2Q2 is upregulated in gastric cancer tissues/cells and promotes malignant phenotypes (proliferation, migration/invasion, metastasis) while enhancing glycolysis and suppressing autophagy. Mechanistically, it functions as a ceRNA by sponging miR-370-3p to de-repress STAT3 signaling, and it can also be packaged into exosomes to promote metastatic behavior via intercellular communication. |
| Confidence score: |
0.8837 |