| Expression pattern: |
UP |
| Associated gene: |
DND1 |
| Associated microRNA: |
- |
| Biological function: |
promotes melanoma cell proliferation, migration, invasion, and tumor growth; inhibits apoptosis |
| Molecular mechanism: |
circFCHO2 directly binds the RNA-binding protein DND1, relieving DND1-mediated inhibition of the PI3K/AKT signaling pathway and increasing AKT phosphorylation. |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Transfection; Colony Formation Assay; CCK8; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
High circFCHO2 expression correlates with malignant phenotype and poor prognosis, and is an independent risk factor for OS and DFS in melanoma patients. |
| Description: |
circFCHO2 (hsa_circ_0002490), derived from the FCHO2 gene, is up-regulated in melanoma and mainly localized in the cytoplasm. It promotes melanoma proliferation, migration, invasion and xenograft growth by directly binding the RBP DND1, thereby relieving DND1-mediated suppression of PI3K/AKT signaling (increasing p-AKT). High circFCHO2 expression is associated with worse OS/DFS and serves as an independent prognostic risk factor. |
| Confidence score: |
0.8792 |