| Expression pattern: |
DN |
| Associated gene: |
E2F7, SLC7A11, GPX4 |
| Associated microRNA: |
miR-302a |
| Biological function: |
Inhibits DEX-induced ferroptotic cell death and oxidative stress in gastric cancer cells; promotes cell survival under DEX treatment. |
| Molecular mechanism: |
ceRNA mechanism: circ0008035 sponges miR-302a to positively regulate E2F7, thereby modulating ferroptosis-related markers (SLC7A11, GPX4) and ROS/iron/GSH balance. |
| Biological pathway or process: |
ferroptosis (inhibits); oxidative phosphorylation (unclear); apoptosis (other); proliferation (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Transfection; Luciferase Reporter Assay; CCK8; EdU Staining; Flow Cytometry（Non-apoptosis/cycle）; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL |
| Clinical significance: |
- |
| Description: |
In gastric cancer cells, DEX decreases circ0008035, promoting ferroptosis. circ0008035 counteracts DEX-induced ferroptotic cell death by sponging miR-302a to maintain E2F7 expression, affecting ROS/iron/GSH and GPX4/SLC7A11 levels. |
| Confidence score: |
0.6835 |