circRNA basic information
circBase ID: -
Name: hsa_circ_PRMT1
Synonym: circ-PRMT1-68
Host Gene: PRMT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MDA-MB-453
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: miR-4284, miR-24-3p
Biological function: might modulate breast cancer cell survival (predicted via miRNA sponging)
Molecular mechanism: putative miRNA sponging (predicted miRNA-binding sites)
Biological pathway or process:

ceRNA regulation (other); proliferation (other)
Detected method:
S
Validation methods:

divergent primers PCR; circRNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

circ-PRMT1-68 is a PRMT1-derived circRNA detected by targeted nanopore circRNA sequencing in breast cancer cells. The study predicts miRNA-binding sites (miR-4284 and miR-24-3p), suggesting a potential miRNA-sponge role that may affect breast cancer cell survival, but this function is not experimentally validated.
Confidence score:

0.3528
Other information
Title:

Targeted nanopore sequencing for the identification of novel PRMT1 circRNAs unveils a diverse transcriptional profile of this gene in breast cancer cells.

Journal: Genes & diseases
Published: 2024
PubMed ID: 37692475
Study type:

biological research
Data availability: Supplementary data to this article can be found online at https://doi.org/10.1016/j.gendis.2023.04.013.
Code availability: -