circRNA basic information
circBase ID: -
Name: hsa_circ_TREM2
Synonym: circTREM2_1
Host Gene: TREM2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004975
MONDO name: Alzheimer disease
Disease details: Alzheimer's disease / AD
Disease DO ID:
 10652
Disease MeSH ID:
 D000544
Disease NCIt ID:
 C2866
Disease ICD11 ID:
 1611724421
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

entorhinal cortex
Cell lines:

HMC3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-765, hsa-miR-11181-3p, hsa-miR-6890-3p, hsa-miR-6766-5p, hsa-miR-6756-5p, hsa-miR-653-3p, hsa-miR-6770-5p, hsa-miR-6131, hsa-miR-6762-3p, hsa-miR-4783-3p, hsa-miR-2392, hsa-miR-4483, hsa-miR-6745
Biological function: Negatively correlated with Abeta deposits in the entorhinal cortex of AD patients.
Molecular mechanism: Bioinformatically predicted miRNA binding (potential miRNA sponge) and potential competition with linear TREM2 transcripts (hypothesized).
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
Validation methods:

divergent primers PCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

This study identifies a TREM2-derived circRNA, circTREM2_1, in human entorhinal cortex and microglial HMC3 cells. circTREM2_1 shows increased expression in AD versus controls by RT-qPCR and its expression negatively correlates with Abeta deposit area in AD cases. Predicted miRNA binding suggests a potential miRNA-sponge/ceRNA-related role, but functional mechanisms remain unvalidated.
Confidence score:

0.5841
Other information
Title:

Profile of TREM2-Derived circRNA and mRNA Variants in the Entorhinal Cortex of Alzheimer's Disease Patients.

Journal: International journal of molecular sciences
Published: 2022
PubMed ID: 35887031
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -