circRNA basic information
circBase ID: hsa_circ_0007624
Name: hsa_circ_BCAR3
Synonym: CircBCAR3
Host Gene: BCAR3
Genomic location(hg19): chr1:94047857-94057950:-
Genomic location(hg38): chr1:93582300-93592393:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007576
MONDO name: esophageal cancer
Disease details: Esophageal cancer / EC
Disease DO ID:
 5041
Disease MeSH ID:
 -
Disease NCIt ID:
 C7478
Disease ICD11 ID:
 669033105
Disease OMIM ID:
 133239
Species: Human
Species details: Homo sapiens
Tissue specimen:

esophageal cancerous specimens; adjacent noncancerous specimens
Cell lines:

EC109; KYSE30; KYSE70; KYSE150; KYSE180; KYSE450; Het-1A
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TNPO1, QKI, E2F7, Ago2
Associated microRNA: miR-27a-3p
Biological function: promotes proliferation; promotes migration; promotes invasion; promotes ferroptosis; promotes tumor growth and metastasis
Molecular mechanism: ceRNA sponging miR-27a-3p to upregulate TNPO1; QKI promotes circBCAR3 biogenesis via intronic binding; hypoxia-induced E2F7 transcriptionally activates QKI
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ferroptosis (promotes); ceRNA regulation (promotes); metastasis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; divergent primers PCR; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; Flow Cytometry（Non-apoptosis/cycle）; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry)
Clinical significance:

circBCAR3 has close association with tumor grading
Description:

circBCAR3 is upregulated in esophageal cancer and further induced by hypoxia. It promotes proliferation, migration, invasion, tumor growth/metastasis and enhances ferroptosis, mainly via a ceRNA mechanism (circBCAR3/miR-27a-3p/TNPO1); its biogenesis is promoted by QKI, which is transcriptionally activated by hypoxia-induced E2F7.
Confidence score:

0.8279
Other information
Title:

CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p.

Journal: Molecular cancer
Published: 2022
PubMed ID: 35840974
Study type:

combined biological and clinical study
Data availability: GSE150476; GSE112496
Code availability: -