circRNA basic information
circBase ID: -
Name: hsa_circ_FBXW7
Synonym: circFBXW7
Host Gene: FBXW7
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia / AML
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

whole blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential tumor suppressor role in AML (discussion); clinically useful for distinguishing AML from controls by ROC.
Molecular mechanism: Not established in this study; discussed that depletion increases proliferative capacity of AML cell lines (from prior work).
Biological pathway or process:

proliferation (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Diagnostic biomarker for AML (AUC 0.826).
Description:

circFBXW7 is down-regulated in AML whole blood and can distinguish AML patients from controls (AUC 0.826). The study did not find significant associations between circFBXW7 expression groups and clinical parameters including survival, but discussion cites prior work suggesting a tumor-suppressive effect where depletion increases AML cell proliferation.
Confidence score:

0.4187
Other information
Title:

Deregulation of CircANXA2, Circ0075001, and CircFBXW7 Gene Expressions and Their Predictive Value in Egyptian Acute Myeloid Leukemia Patients.

Journal: The application of clinical genetics
Published: 2022
PubMed ID: 35874179
Study type:

clinical study
Data availability: The datasets generated and analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request.
Code availability: -