circRNA basic information
circBase ID: -
Name: hsa_circ_ANXA2
Synonym: circANXA2 / circ-ANXA2
Host Gene: ANXA2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia / AML
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

whole blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ANXA2
Associated microRNA: MiR-23a-5p, miR503-3p
Biological function: Associated with shorter overall survival and adverse cytogenetic pattern; predicts lower CR achievement in AML patients.
Molecular mechanism: miRNA sponge (ceRNA-like): sponges MiR-23a-5p and miR503-3p; reported to augment transcription of parental gene ANXA2 and may reduce chemosensitivity.
Biological pathway or process:

ceRNA regulation (other); chemoresistance (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis
Clinical significance:

Diagnostic biomarker for AML (AUC 0.824); high expression correlates with shorter overall survival and adverse cytogenetic pattern; independent predictor of CR achievement.
Description:

circANXA2 is up-regulated in AML whole blood and has diagnostic value (AUC 0.824). High circANXA2 associates with adverse clinical features and shorter overall survival, and it is an independent predictor of complete remission achievement. Mechanistically, it is discussed as a miRNA sponge (MiR-23a-5p/miR503-3p) and linked to ANXA2 transcription and chemotherapy sensitivity.
Confidence score:

0.4758
Other information
Title:

Deregulation of CircANXA2, Circ0075001, and CircFBXW7 Gene Expressions and Their Predictive Value in Egyptian Acute Myeloid Leukemia Patients.

Journal: The application of clinical genetics
Published: 2022
PubMed ID: 35874179
Study type:

clinical study
Data availability: The datasets generated and analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request.
Code availability: -