circRNA basic information
circBase ID: hsa_circ_0001493
Name: hsa_circ_ERBB2IP
Synonym: circ_0001493
Host Gene: ERBB2IP
Genomic location(hg19): chr5:65284462-65310553:+
Genomic location(hg38): chr5:65988634-66014725:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005306
MONDO name: ankylosing spondylitis
Disease details: ankylosing spondylitis / AS
Disease DO ID:
 7147
Disease MeSH ID:
 D013167
Disease NCIt ID:
 C84564
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ERBB2IP, ALP, OSX
Associated microRNA: miR-582-3p
Biological function: promotes osteogenesis
Molecular mechanism: Validated inverse expression relationship with miR-582-3p (circRNA-miRNA network).
Biological pathway or process:

ceRNA regulation (other); proliferation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Transfection; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0001493 (from ERBB2IP) is down-regulated in osteogenically differentiated AS-BMSCs but functionally promotes osteogenesis in both HD- and AS-BMSCs, since its knockdown reduces mineralization and osteogenic markers. The circRNA-miRNA network with miR-582-3p was supported by qPCR-consistent inverse expression.
Confidence score:

0.695
Other information
Title:

RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis.

Journal: Frontiers in genetics
Published: 2022
PubMed ID: 35873481
Study type:

combined biological and clinical study
Data availability: https://www.frontiersin.org/articles/10.3389/fgene.2022.947120/full#supplementary-material
Code availability: -