| Expression pattern: |
UP |
| Associated gene: |
FCGR3A, FCGR3B |
| Associated microRNA: |
hsa-miR-942-5p |
| Biological function: |
Potential circulating diagnostic biomarker for AIS; elevated in TIA and may predict TIA risk; may be involved in post-stroke immune/inflammatory responses. |
| Molecular mechanism: |
Predicted ceRNA mechanism: circPTP4A2 may sponge hsa-miR-942-5p to regulate FCGR3A/FCGR3B in AIS immune-related ceRNA network. |
| Biological pathway or process: |
ceRNA regulation (other); inflammation (other); immune regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Cohort Study; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Plasma circPTP4A2 is increased in AIS vs HCs and TIA, has diagnostic value by ROC, and is an independent risk factor for predicting TIA. |
| Description: |
circPTP4A2 (hsa_circ_0007364) is up-regulated in plasma of AIS patients and also elevated in TIA vs healthy controls, supporting its use as a circulating diagnostic/predictive biomarker. Mechanistically, the study predicts a ceRNA axis in which circPTP4A2 sponges hsa-miR-942-5p to influence FCGR3A/FCGR3B within an immune-related network, though functional validation is not performed. |
| Confidence score: |
0.5534 |