circRNA basic information
circBase ID: hsa_circ_0004771
Name: hsa_circ_NRIP1
Synonym: hsa_circRNA_103110
Host Gene: NRIP1
Genomic location(hg19): chr21:16386664-16415895:-
Genomic location(hg38): chr21:15014343-15043574:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004781
MONDO name: acute myocardial infarction
Disease details: acute myocardial infarction / AMI
Disease DO ID:
 9408
Disease MeSH ID:
 -
Disease NCIt ID:
 C35204
Disease ICD11 ID:
 1334938734
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

Blood
Cell lines:

AC16
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: SRSF1
Associated microRNA: hsa-miR-629-3p
Biological function: Potential AMI biomarker; proposed to be involved in AMI via the hsa-miR-629-3p/SRSF1 axis.
Molecular mechanism: Putative ceRNA axis involving hsa-miR-629-3p and SRSF1.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis; Transfection
Clinical significance:

Identified as a potential biomarker in AMI.
Description:

hsa_circ_0004771 is down-regulated in AMI blood microarray data and in an AC16 hypoxia model. The study proposes a ceRNA axis hsa_circ_0004771/hsa-miR-629-3p/SRSF1 potentially involved in myocardial infarction, and lists it as a potential biomarker.
Confidence score:

0.3684
Other information
Title:

Comprehensive Analysis of circRNA-miRNA-mRNA Regulatory Network and Novel Potential Biomarkers in Acute Myocardial Infarction.

Journal: Frontiers in cardiovascular medicine
Published: 2022
PubMed ID: 35872921
Study type:

combined biological and clinical study
Data availability: GSE160717; GSE31568; GSE61741; GSE24519; GSE66360; https://www.frontiersin.org/articles/10.3389/fcvm.2022.850991/full#supplementary-material
Code availability: -