| Expression pattern: |
UP |
| Associated gene: |
UPF1, ATF3, Nestin |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation; promotes invasion; promotes self-renewal/stemness; promotes tumorigenesis |
| Molecular mechanism: |
UPF1 binds circRPPH1 to maintain its stability; circRPPH1 binds ATF3 to protect ATF3 from degradation and promote nuclear translocation; ATF3 transcriptionally upregulates UPF1 and Nestin forming a positive feedback loop; pathway activation of TGF-beta1/Smad2/3 |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); stemness (promotes); TGF-beta/SMAD (promotes); other pathway/process (promotes) |
| Detected method: |
Q
B
H
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; RNase R Treatment; Northern Blot; FISH / smFISH; Sanger Sequencing; RIP (RNA Immunoprecipitation); RNA Pull-Down; Actinomycin D / DRB Stability Assay; Transfection; MTT; EdU Staining; Transwell Assay; Western Blot; Luciferase Reporter Assay; ChIP / ChIP-seq; ELISA; IF (Immunofluorescence); Nuclear-Cytoplasmic Fractionation; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Survival Analysis |
| Clinical significance: |
High circRPPH1 expression is associated with higher WHO grade and shorter median survival time / poor prognosis in glioma patients. |
| Description: |
circRPPH1 is up-regulated in GBM/GSCs and promotes malignant phenotypes (proliferation, invasion, self-renewal and tumorigenesis). UPF1 binds circRPPH1 to maintain its stability, while circRPPH1 binds ATF3 to stabilize it and promote nuclear translocation; ATF3 transcriptionally upregulates UPF1 and Nestin, forming a positive feedback loop and enhancing TGF-beta/SMAD signaling. |
| Confidence score: |
0.8941 |