| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-34a |
| Biological function: |
Promotes MCL cell proliferation by sponging miR-34a and counteracting miR-34a-mediated growth inhibition. |
| Molecular mechanism: |
circCTNNA1 directly binds (sponges) miR-34a; the two do not regulate each other’s expression levels. |
| Biological pathway or process: |
proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNA Pull-Down; Transfection; BrdU; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression levels of circCTNNA1 predicted the poor survival of MCL patients; circCTNNA1 was a significant prognostic factor for overall survival. |
| Description: |
circCTNNA1 is up-regulated in mantle cell lymphoma and functions as an oncogenic circRNA. It directly binds (sponges) miR-34a and promotes MCL cell proliferation, and higher circCTNNA1 expression predicts poorer overall survival. |
| Confidence score: |
0.7083 |