| Expression pattern: |
UP |
| Associated gene: |
EPSTI1, ZNF704, POU2F2 |
| Associated microRNA: |
hsa-miR-942-5p, hsa-miR-4753-3p, hsa-miR-6739-3p |
| Biological function: |
May function as a miRNA sponge (ceRNA) to regulate EPSTI1 expression in the AD continuum. |
| Molecular mechanism: |
ceRNA/miRNA sponging: hsa_circRNA_000479 binds miRNAs (validated for hsa-miR-942-5p, hsa-miR-4753-3p, hsa-miR-6739-3p) to regulate target gene expression (EPSTI1). |
| Biological pathway or process: |
ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Luciferase Reporter Assay; Transfection; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
May be a non-invasive biomarker for early stage AD patient screening tests. |
| Description: |
hsa_circRNA_000479 is up-regulated in blood across AD continuum stages and is suggested as an early, non-invasive screening biomarker. It likely functions via a ceRNA mechanism, sponging miRNAs (validated for hsa-miR-942-5p, hsa-miR-4753-3p, and hsa-miR-6739-3p) to regulate EPSTI1 expression. |
| Confidence score: |
0.5922 |