| Expression pattern: |
UP |
| Associated gene: |
EMB, POU2AF1, AMMECR1 |
| Associated microRNA: |
hsa-miR-548m, hsa-miR-1252-5p, hsa-miR-4644 |
| Biological function: |
May function as a miRNA sponge (ceRNA) to regulate EMB expression in the AD continuum. |
| Molecular mechanism: |
ceRNA/miRNA sponging: hsa_circRNA_001481 binds miRNAs (e.g., hsa-miR-548m, hsa-miR-1252-5p, hsa-miR-4644) to regulate target gene expression (EMB). |
| Biological pathway or process: |
ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Luciferase Reporter Assay; Transfection; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Proposed as a potential biomarker for early stage AD (SCD and aMCI) in blood. |
| Description: |
hsa_circRNA_001481 is up-regulated in blood from early AD continuum stages (SCD/aMCI) and is proposed as a non-invasive early diagnostic biomarker. Mechanistically, it acts as a ceRNA by sponging miRNAs (validated for hsa-miR-548m, hsa-miR-1252-5p, and hsa-miR-4644), thereby modulating EMB expression. |
| Confidence score: |
0.5922 |