| Expression pattern: |
UP |
| Associated gene: |
ARHGAP5, IGF2BP3, HDAC4 |
| Associated microRNA: |
miR-653-5p, miR-502-5p |
| Biological function: |
promotes prostate cancer cell migration and metastasis by inducing EMT |
| Molecular mechanism: |
acts as a miRNA sponge for miR-653-5p to elevate ARHGAP5; binds IGF2BP3 in cytoplasm to enhance HDAC4 mRNA stability and activate ERK signaling, promoting EMT and metastasis |
| Biological pathway or process: |
ERK (promotes); MAPK (promotes); EMT (promotes); migration (promotes); metastasis (promotes); mRNA stability (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
S
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ISH (In Situ Hybridization); FISH / smFISH; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; Wound Healing Assay; Transwell Assay; CCK8; Colony Formation Assay; RNA-seq; Western Blot; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; IF (Immunofluorescence); MeRIP / MeRIP-seq; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Increased expression in PCa tissues was associated with advanced TNM stage and ISUP grade; may act as a biomarker for metastasis of PCa |
| Description: |
hsa_circ_0003258 is up-regulated in prostate cancer tissues and promotes migration/metastasis. It sponges miR-653-5p to increase ARHGAP5 and also forms a cytoplasmic complex with IGF2BP3 to stabilize HDAC4 mRNA, activating ERK/MAPK-driven EMT. |
| Confidence score: |
0.8983 |