circRNA basic information
circBase ID: -
Name: hsa_circ_UBQLN1
Synonym: circUBQLN1
Host Gene: UBQLN1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; normal para-cancerous tissue; peritumoral normal tissue
Cell lines:

FHC; RKO; Colo320; SW480; SW620; LOVO; THP-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CSF1R, AGO2
Associated microRNA: miR-499a, miR-499b-5p, miR-34c-5p, miR-3605-5p
Biological function: Promotes M2-type polarization of TAMs, enhances CRC cell proliferation, migration, invasion, metastasis, and tumor progression through exosome-mediated intercellular communication.
Molecular mechanism: Exosomal circUBQLN1 competitively binds miR-34c-5p, weakens miR-34c-5p-mediated inhibition of CSF1R, and activates the circUBQLN1/miR-34c-5p/CSF1R axis to promote TAM M2 polarization and CRC progression.
Biological pathway or process:

ceRNA regulation (other); immune regulation (promotes); macrophage polarization (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; Western Blot; Flow Cytometry（Non-apoptosis/cycle）; In Vivo Animal Model
Clinical significance:

circUBQLN1 could be a possible target for Exo-mediated tumor immune modulation in CRC.
Description:

circUBQLN1 is up-regulated in CRC tissues, CRC cell lines, CRC-derived exosomes, and TAMs exposed to CRC-derived exosomes. CRC cell-derived exosomal circUBQLN1 promotes TAM M2 polarization by sponging miR-34c-5p and derepressing CSF1R, thereby enhancing CRC cell growth, migration, invasion, and metastasis.
Confidence score:

0.7289
Other information
Title:

Exosomal circUBQLN1 facilitates M2 polarization of macrophages and enhances colorectal cancer progression by modulating the miR-34c-5p/CSF1R axis.

Journal: Pathology, research and practice
Published: 2025
PubMed ID: 40460641
Study type:

combined biological and clinical study
Data availability: -
Code availability: -