circRNA basic information
circBase ID: hsa_circ_0068669
Name: hsa_circ_SENP5
Synonym: hsa_circ_103561
Host Gene: SENP5
Genomic location(hg19): chr3:196612021-196613565:+
Genomic location(hg38): chr3:196885150-196886694:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; paired adjacent non-tumorous tissues; adjacent normal liver tissues; chronic hepatitis tissues; liver biopsy tissues
Cell lines:

HepG2; Huh-7; SMMC-7721; MHCC-97L; MHCC-97H; HCC-LM3; L-02
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: hsa_circ_0068669 is downregulated in HCC tissues and HCC cell lines, is associated with microvascular invasion and TNM stages, and may serve as an indicator or biomarker of HCC invasion and metastasis.
Molecular mechanism: No direct molecular mechanism was experimentally defined; the study mainly reports differential expression and clinical association with metastasis-related features.
Biological pathway or process:

metastasis (inhibits); invasion (inhibits)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis
Clinical significance:

hsa_circ_0068669 might serve as a novel potential biomarker for HCC metastasis; its expression was correlated with microvascular invasion and TNM stages, and ROC analysis showed AUC 0.64 with sensitivity 59% and specificity 71%.
Description:

This study identifies hsa_circ_0068669, a SENP5-derived human circRNA, as significantly downregulated in HCC tissues and HCC cell lines. Its low expression is associated with metastasis-related clinicopathological features including microvascular invasion and TNM stage, supporting its potential value as a biomarker for HCC metastasis rather than establishing a mechanistic regulatory axis.
Confidence score:

0.5662
Other information
Title:

Circular RNA 0068669 as a new biomarker for hepatocellular carcinoma metastasis.

Journal: Journal of clinical laboratory analysis
Published: 2018
PubMed ID: 29785842
Study type:

combined biological and clinical study
Data availability: GSE94508; GEO No. 94508: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE94508; circBase: http://www.circbase.org/cgi-bin/simplesearch.cgi
Code availability: -